Priority reviews

Priority reviews

Review priority areas

About the ARI Group’s priority-setting project

Cochrane’s policy and procedures have evolved to establish priority areas for reviews. We define priority setting as making informed decisions about review topics to ensure that concepts identified through consultation with health professionals, consumer representatives, and other stakeholders, are met. The purpose of the project was to identify priority topics of interest to our stakeholders for review.

Our priority-setting work involved three components: a stakeholder Delphi survey; a gap analysis of available randomised controlled trial (RCT) evidence that was compared with registered review titles; and analysis of topics searched via the Trip database.

Governance

We established a steering group to lead the priority-setting process:

  • Professor Chris Del Mar, Cochrane ARI Group Co-ordinating Editor, Director of Centre for Research in Evidence-Based Practice (CREBP) (Bond University, Australia);
  • Dr Mark Jones, Cochrane ARI Group Deputy Co-ordinating Editor (Bond University, Australia);
  • Dr Anna Mae Scott, Senior Research Fellow/Assistant Professor, Centre for Research in Evidence-Based Practice (CREBP) (Bond University, Australia);
  • Justin Clark, Cochrane ARI Group Information Specialist (at the time of the survey);
  • Liz Dooley, Cochrane ARI Group Managing Editor; and
  • Ann Jones, Cochrane ARI Group Managing Editor.

Stakeholder engagement

We are grateful for the support and interest of many external stakeholders who provided data, guidance and feedback. People from a wide range of organisations and agencies helped to promote stakeholder involvement to complete the Delphi survey:

  • Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Australia;
  • Cochrane Knowledge Translation;
  • Cochrane Membership, Learning and Support Services;
  • Cystic fibrosis patient groups;
  • European Patients' Academy (EUPATI) Facebook group;
  • Health Consumers Alliance of South Australia Inc;
  • Health Consumers Queensland, Australia;
  • Health Technology Assessment International (HTAi) Patient/Consumer Interest Group;
  • Institute of Health Economics, Canada; and
  • Lung Cancer Canada.

We are indebted to the Delphi survey respondents. (Responses to the survey were anonymised). We also thank the director of the Trip database.

Priority-setting project components

Delphi survey

We conducted two online surveys with the aim of identifying the top 20 priority systematic reviews from a list of 68 review topics derived from the gap analysis for which evidence was available from more than four RCTs.

We advertised the link to the first survey through a wide range of Cochrane portals, and to ensure a broad response from consumers and patients, we also contacted several consumer health groups in Australia who disseminated the request and survey link to their members.

A second survey asked respondents to choose 10 topics from a list of 25 topics that were identified in the first survey.

The top five priority topics derived from the survey were: vaccinations for acute respiratory infections; antivirals for acute respiratory infections; non-steroidal anti-inflammatories for acute respiratory infections; vitamins and supplements for acute respiratory infections; and infection control for influenza.

Read our published report: Cochrane Acute Respiratory Infections Group's stakeholder engagement project identified systematic review priority areas

Research gaps analysis

We aimed to determine interventions and health conditions for which there are RCTs not systematically reviewed by Cochrane. We used a list of ARI-specific RCTs from our group’s trials register and compared this with a list of Cochrane Reviews specific to our group

The top five priority topics derived from the gap analysis were antibiotics for each pneumonia, acute bronchitis, sore throat, middle ear infection, and sinus infection.

Read our published report: Determining the gaps between Cochrane reviews and trials of effectiveness of interventions for acute respiratory infections: an audit. An interactive data graph is also available.

Trip database analysis

The Trip database is a clinical search engine which aims to help clinicians find the best available evidence to answer a clinical question. Our purpose was to identify topics that stakeholders had asked via this search engine and we extracted relevant searches containing at least one disease and one clinical management term.

The top five priority topics derived from the Trip database analysis were: vaccination for influenza; antibiotics for middle ear infection; vitamin C for the common cold; corticosteroids for meningitis; and treatments for pneumonia.

Read our published report: The Trip database showed most acute respiratory infections questions were already addressed by Cochrane Reviews

Analysis and evaluation

We derived five priority review topic areas from the Delphi survey:

  1. Interventions to prevent acute respiratory infections;
  2. Antivirals for acute respiratory infections;
  3. Nonsteroidal anti-inflammatory drugs for acute respiratory infections;
  4. Vitamins and supplements for acute respiratory infections; and
  5. Infection control and influenza.

We matched existing reviews to these topic areas and used the gap analysis findings to identify additional review topic areas that need to be addressed. We then invited the ARI Group Editors to provide feedback. The Editors provided valuable insights and their guidance has been applied to ensure topics are robust and clinically relevant.

Our priority setting exercise involved a broad range of stakeholders to ensure that topics were clinically and socially relevant, appropriate, and feasible. We experienced challenges: some suggested topics were outside the ARI Group’s scope (such as asthma); were not well defined and could not be matched to a specific health condition or intervention topic (e.g. “ARI non-specific”); or were concepts that did not relate to topics that could inform a population, intervention, comparator, outcomes (PICO) question or are generally treated as intervention review outcomes (e.g. mortality, adverse effects). These topics, and duplicated topics, were excluded from the analysis. We also faced challenges when interpreting feedback relating to complementary and alternative medicines which did not provide enough detail to enable comparison with current reviews, or those that were supportive, rather than complementary, therapies.

We made a post hoc decision to link priority topics to a standardised list of topics supported and managed by the Cochrane ARI Group.

Project time frame

The project was undertaken from 2017 to 2018. We plan to review the relevance of the priority review topics as time and resources permit. At a minimum, we will conduct another priority-setting exercise within five years.

Priority setting findings and review topics

We matched the five priority topics to current titles and used findings from the gaps analysis findings to validate need for possible new reviews. As a result, we will commission four new priority reviews.

Interventions to prevent acute respiratory infections

Two new reviews will be commissioned to investigate:

  • Vaccination for polio; and
  • Palivizumab to prevent respiratory syncytial virus in children.

Antivirals for acute respiratory infections

A new review will be commissioned to investigate:

  • Antivirals for influenza and influenza-like infections

Nonsteroidal anti-inflammatory drugs (NSAIDs) for acute respiratory infections

A new review will be commissioned to investigate:

  • NSAIDs for sore throat (tonsillitis, pharyngitis)

Vitamins and supplements for acute respiratory infections

No priority review topics were identified. The topic is covered by existing reviews, and gap analysis and feedback did not identify further topics for review.

Infection control and influenza

A current review on this topic, Physical interventions to interrupt or reduce the spread of respiratory viruses, will be updated.

Commissioning new teams to undertake priority reviews

We have called for expressions of interest from teams to undertake four new reviews:

  • Vaccination for polio;
  • Palivizumab to prevent respiratory syncytial virus in children;
  • Antivirals for influenza and influenza-like infections; and
  • NSAIDs for sore throat (tonsillitis, pharyngitis).

Proposals were invited from prospective author teams (closed 12 December 2019). Proposals are being assessed by the Cochrane ARI Group editorial base team. We aim that decisions about successful teams will be made by early 2020.

Other review topics

We welcome proposals for reviews, but potential author teams must ensure the topic is globally and clinically relevant, and there is recent or ongoing RCT evidence or research on the topic. We are unable to accept review proposals that investigate topics already covered. Please see Our reviews.